Regina K. Zitter was born in Fort Recovery, Ohio, and moved to Huntington in 1945. Together with some local businessmen, the Zitters started Sterling Supply Company. After the death of her husband, John, in 1972, Zitter took over running the business and was voted "Women in Business Advocate of the Year" in 1991.
To benefit high school students at St. Joseph Catholic High School, she established the Ann Klim Scholarship Fund and the John William Garrett Jr. Memorial Scholarship Fund. She served on many boards of directors in the area, such as Birthright, YMCA, Boys and Girls Clubs of Huntington, Scott Community Center (where she endowed the Maudella Taylor Foundation), United Way of the River Cities, Junior Achievement, the John Marshall Society and the Dr. Carter G. Woodson Foundation.
Zitter started a one-woman campaign to raise funds to build restrooms at the Ritter Park Amphitheater. She also donated the gazebo located atop Gobbler's Knob and contributed to the footbridge just below the rose garden.